More setbacks could well affect the entire season and increase the pressure on coach Lucien Favre at an early stage.
Atletico Madrid were unable to repeat the performance that gave them a 6-1 win over Granada at the weekend, as they were held 0-0 away to recently promoted Huesca.
By contrast, Bottas, who had started third, inherited the lead after Hamilton's pit stop, and was able to make his own stop on lap 27 without losing the first place that he would then hold to the end.
Meanwhile left back Marcelo is also struggling with a back injury and Ferland Mendy will continue in defense.
The swimmers' performances at the championships will act as an important reference for their qualification for next year's Tokyo Olympic Games. Enditem
Rookie Zhang Ke, 19, took first place in the final of the women's 1,500m freestyle in 16:13.26. Wang Jianjiahe, who broke the Asian record of the event in the preliminary heat, also missed the final due to physical tests results.
With the score tied at 68-all before the final quarter, Sichuan took charge of the last 10 minutes despite Shao's departure.
RIO DE JANEIRO, Sept. 30 (Xinhua) -- Substitute Bruno Henrique scored twice as Brazil's Flamengo beat Ecuadorian side Independiente del Valle 4-0 in their Copa Libertadores Group A match on Wednesday.
Olimpia is the most successful club in Paraguayan football, having won the country's first division title a record 44 times and the Copa Libertadores three times. Enditem
"With the establishment of the World Athletics Road Running Championships, the whole global community of recreational runners, which numbers in the millions, will be able to come together to celebrate their passion for putting foot to the road."
Baena, the world number 101, battled to a 7-5, 6-7, 6-3, 3-6, 8-6 victory to reach the third round of a Grand Slam for the first time in his career.